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Professor Giulia Iori
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- Department of Economics,
- School of Social Science
- City University,
- Northampton Square,
- London EC1V 0HB.
- Phone +44-020-7040-4575
- Fax + 44-020-7040-8580
Protein Folding
My PhD thesis focused on the study of polymeric chains with random self-interactions. In collaboration with E. Marinari and G. Parisi, we investigated using Monte Carlo simulations the thermodynamic behavior of a linear heteropolymer in which the interactions between different monomers contain a quenched random component. We showed the existence, along with the usual coil and globule phases, of a new folded phase, characterised by long relaxation times and by the existence of few stable states. We studied the dynamics of the heteropolymeric chain relaxing toward a new equilibrium configuration after the action of an external perturbation. We compared the results of Monte Carlo simulations with the results of a Langevin normal mode decomposition and discussed the case of an ordered homopolymeric chain.
- G.Iori, E.Marinari and G.Parisi Random self-interacting chains: a mechanism for protein folding J. Phys A 24 (1991) 5349-5362.
- G.Iori Proteins and Random Heteropolymers: an Overview Int. J. of Neural Systems Vol. 3 (Supp. 1992) 201-207
- G.Iori, E.Marinari, G.Parisi and M.V.Struglia, Statistical Mechanics of Heteropolymer Folding Physica A 185 (1992) 98-103
- G.Iori, E.Marinari, G.Parisi Heteropolymer Folding on a APE-100 Supercomputer Int. J. of Mod. Phys. C, Vol 4, No. 6 (1993) 1333-1341
- G.Iori, E.Marinari, G.Parisi Non exponential relaxation time scales in disordered systems: an application to protein dynamics Europhys. Lett. Vol 25, No. 7, (1994) 491-496
- G. Iori, E. Marinari On the stability of the mean-field spin glass broken phase under non-Hamiltonian perturbations J. Phys. A: Math. Gen. 30 4489-4511 (1997)