Protein Folding
My PhD thesis focused on the study of polymeric chains with random self-interactions. In collaboration with E. Marinari and G. Parisi, we investigated using Monte Carlo simulations the thermodynamic behavior of a linear heteropolymer in which the interactions between different monomers contain a quenched random component. We showed the existence, along with the usual coil and globule phases, of a new folded phase, characterised by long relaxation times and by the existence of few stable states. We studied the dynamics of the heteropolymeric chain relaxing toward a new equilibrium configuration after the action of an external perturbation. We compared the results of Monte Carlo simulations with the results of a Langevin normal mode decomposition and discussed the case of an ordered homopolymeric chain.
- G.Iori, E.Marinari, G.Parisi
Non exponential relaxation time scales in disordered systems: an application to protein dynamics
Europhys. Lett. Vol 25, No. 7, (1994) 491-496
- G. Iori, E. Marinari
On the stability of the mean-field spin glass broken phase under non-Hamiltonian perturbations
J. Phys. A: Math. Gen. 30 4489-4511 (1997)
- G.Iori, E.Marinari, G.Parisi
Heteropolymer Folding on a APE-100 Supercomputer
Int. J. of Mod. Phys. C, Vol 4, No. 6 (1993) 1333-1341
- G.Iori
Proteins and Random Heteropolymers: an Overview
Int. J. of Neural Systems Vol. 3 (Supp. 1992) 201-207
- G.Iori, E.Marinari, G.Parisi and M.V.Struglia,
Statistical Mechanics of Heteropolymer Folding
Physica A 185 (1992) 98-103
- G.Iori, E.Marinari and G.Parisi
Random self-interacting chains: a mechanism for protein folding
J. Phys A 24 (1991) 5349-5362.
- G.Iori, E.Marinari, G.Parisi
Non exponential relaxation time scales in disordered systems: an application to protein dynamics
Europhys. Lett. Vol 25, No. 7, (1994) 491-496
- G. Iori, E. Marinari
On the stability of the mean-field spin glass broken phase under non-Hamiltonian perturbations
J. Phys. A: Math. Gen. 30 4489-4511 (1997)
- G.Iori, E.Marinari, G.Parisi
Heteropolymer Folding on a APE-100 Supercomputer
Int. J. of Mod. Phys. C, Vol 4, No. 6 (1993) 1333-1341
- G.Iori
Proteins and Random Heteropolymers: an Overview
Int. J. of Neural Systems Vol. 3 (Supp. 1992) 201-207
- G.Iori, E.Marinari, G.Parisi and M.V.Struglia,
Statistical Mechanics of Heteropolymer Folding
Physica A 185 (1992) 98-103
- G.Iori, E.Marinari and G.Parisi
Random self-interacting chains: a mechanism for protein folding
J. Phys A 24 (1991) 5349-5362.
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